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Enhancing in vitro osteogenic differentiation of mesenchymal stem cells via sustained dexamethasone delivery in 3D Printed hybrid scaffolds based on polycaprolactone nanohydroxyapatite/alginate gelatin for bone regeneration
https://cmfrc.tums.ac.ir//Article/Enhancing-in-vitro-osteogenic-differentiation-of-mesenchymal-stem-cells-via-sustained-dexamethasone-delivery-in-3D-Printed-hybrid-scaffolds-based-on-polycaprolactone-nanohydroxyapatite⁄alginate-gelatin-for-bone-regeneration
Abstract Despite the natural ability of bone repair, its limitations have led to advanced organic-inorganic-based biomimetic scaffolds and sustained drug release approaches. Particularly, dexamethasone (DEX), a widely used synthetic glucocorticoid, has been shown to increase the expression of bone-related genes during the osteogenesis process. This study aims to develop a hybrid 3D-printed scaffold for controlled delivery of dexamethasone. Hence, hybrid scaffolds were fabricated using a layer-by
Therapeutic potential of exosomes derived from human endometrial mesenchymal stem cells for heart tissue regeneration after myocardial infarction
https://cmfrc.tums.ac.ir//news/Therapeutic-potential-of-exosomes-derived-from-human-endometrial-mesenchymal-stem-cells-for-heart-tissue-regeneration-after-myocardial-infarction/290216
Abstract Myocardial infarction (MI) is the most common cardiovascular disease (CVD) and the leading cause of mortality worldwide. Recent advancements have identified human endometrial mesenchymal stem cells (hEnMSCs) as a promising candidate for heart regeneration, however, challenges associated with cell-based therapies have shifted focus toward cell-free treatments (CFTs), such as exosome therapy, which show considerable promise for myocardial tissue regeneration. MI was induced in male Wistar
Osteogenic differentiation of follicular stem cells on nano Saghez scaffold containing BMP2
https://cmfrc.tums.ac.ir//article/Osteogenic-differentiation-of-follicular-stem-cells-on-nano-Saghez-scaffold-containing-BMP2
Abstract Background Bone tissue is one of the tissues that are capable of self-regeneration. However, bone self-regeneration is defeated in the case of broad lesion of bone structure. Isolated stem cells from wisdom tooth follicles can potentially differentiate into ectodermal and mesodermal cells. Saghez is a natural substance that has been extracted from Pistacia terebinthus with unique features, such as high temperature and mechanical stability, adhesive structure, biocompatibility, and anti-
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