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Decellularized myocardial patch functionalized with stem cell derived exosomes improves cardiac healing after infarction
https://cmfrc.tums.ac.ir//article/Decellularized-myocardial-patch-functionalized-with-stem-cell-derived-exosomes-improves-cardiac-healing-after-infarction
Abstract Acute myocardial infarction (AMI) leads to irreversible cardiomyocyte loss, extracellular matrix (ECM) disruption, and progressive ventricular remodeling, for which effective regenerative therapies remain limited. While cell-based cardiac patches have shown promise, their clinical translation is hindered by poor graft survival, immune incompatibility, and safety concerns. Acellular ECM-based scaffolds offer a safer alternative but lack sufficient biological activity to drive robust repa
Exosomal mRNAs/microRNAs in Osteogenesis and Bone Regeneration: From Signaling to Therapeutic Roles
https://cmfrc.tums.ac.ir//Article/Exosomal-mRNAs⁄microRNAs-in-Osteogenesis-and-Bone-Regeneration:-From-Signaling-to-Therapeutic-Roles
Abstract Bone regeneration remains a significant clinical challenge in conditions such as trauma, osteoporosis, and aging-related bone loss. Recent advances have highlighted the crucial role of extracellular vesicles, especially exosomes, in intercellular signaling pathways that support bone homeostasis and repair. Among their bioactive cargoes, exosomal RNAs—particularly messenger RNAs and microRNAs—have emerged as central regulators of osteogenesis by modulating gene expression, ce
Exosome functionalized collagen coated 3D printed PCL scaffold for enhanced osteogenic differentiation and bone regeneration
https://cmfrc.tums.ac.ir//article/Exosome-functionalized-collagen-coated-3D-printed-PCL-scaffold-for-enhanced-osteogenic-differentiation-and-bone-regeneration
Article_DOI https//link.springer.com/article/10.1186/s13036-025-00578-w abdolreza mohamadnia,naghmeh bahrami, mohammad bayat,jafar ai,fatemeh ghorbani shemshadsara کارشناس مقالات,مقالات 312127 مدیر سیستم دانلود فایل *
Therapeutic potential of exosomes derived from human endometrial mesenchymal stem cells for heart tissue regeneration after myocardial infarction
https://cmfrc.tums.ac.ir//news/Therapeutic-potential-of-exosomes-derived-from-human-endometrial-mesenchymal-stem-cells-for-heart-tissue-regeneration-after-myocardial-infarction/290216
Abstract Myocardial infarction (MI) is the most common cardiovascular disease (CVD) and the leading cause of mortality worldwide. Recent advancements have identified human endometrial mesenchymal stem cells (hEnMSCs) as a promising candidate for heart regeneration, however, challenges associated with cell-based therapies have shifted focus toward cell-free treatments (CFTs), such as exosome therapy, which show considerable promise for myocardial tissue regeneration. MI was induced in male Wistar
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