Investigating the Level of MUC5B Expression in the Plasma of Patients with Idiopathic Pulmonary Fibrosis (IPF) Compared to Healthy Individuals

https://cmfrc.tums.ac.ir//article/Investigating-the-Level-of-MUC5B-Expression-in-the-Plasma-of-Patients-with-Idiopathic-Pulmonary-Fibrosis-(IPF)-Compared-to-Healthy-Individuals

Abstract Introduction Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease associated with high morbidity and mortality. Genetic factors, particularly the MUC5B promoter polymorphism, have been strongly implicated in disease pathogenesis. Given the shared embryological origin of the respiratory and oral epithelia, investigating systemic MUC5B expression may provide insights relevant to craniofacial and mucosal health. This study aimed to evaluate MUC5B gene expression i