Summary of the Rationale for Conducting the Study

The skin, as the largest organ of the human body, serves as the first line of defense against pathogenic factors. Skin aging is a multifactorial process influenced by intrinsic and extrinsic factors as well as structural changes in the skin layers, leading to reduced collagen synthesis and degradation of the extracellular matrix. The face and neck regions are of particular importance due to their constant exposure and visibility. The active compounds present in aloe vera extract and the anti-wrinkle peptide acetyl hexapeptide-8 are both well known for their anti-aging properties; however, limitations such as low permeability, poor stability, and short half-life reduce their effectiveness. Nanoliposomes, due to their ability to enhance bioavailability, penetration, and stability of active compounds, represent a suitable strategy for improving the biological efficacy of these agents. The aim of this study is to synthesize and evaluate nanoliposomes containing acetyl hexapeptide-8 and aloe vera extract, and to investigate their effects on cell viability and the expression of genes related to collagen synthesis in human dermal fibroblast (HDF) cells. The development of nano-based systems containing anti-aging compounds, through increased collagen synthesis and reduced extracellular matrix degradation, offers an effective and safer alternative to invasive methods such as botulinum toxin injections. This study may represent an important step toward the development of novel anti-aging formulations and cosmeceutical products based on nanotechnology.

Principal Investigator: Dr. Zahra Azizi
Start Year: 1404