Summary of the necessity of project implementation

Bone regeneration in skull, jaw and face surgeries is an issue that includes both reconstructive and aesthetic aspects. Treatment of bone defects with critical or non-uniform size caused by congenital diseases, accidents or removal of cancerous areas often requires bone grafting. Using autologous transplantation as the standard treatment can be painful, cause co-morbidities, and cost a lot. Tissue engineering products regenerate damaged bone in the jaw and face by combining biodegradable scaffolds with bioactive factors and cells. The use of the 3D printing method in the preparation of scaffolds makes it possible to make a suitable and special scaffold for each patient with a unique geometry through the conversion of CT images into printer code. Also, the possibility of designing the desired internal structure for the scaffold to achieve desirable mechanical and biological properties can be pursued using 3D printing. The combination of 3D bioprinting technology with materials extracted from decellularized tissues facilitates the construction of scaffolds capable of imitating the natural tissue environment and with high therapeutic potential. Therefore, in this plan, it is proposed to use the powder obtained from decellularized bone as a strengthening agent in the field of methacrylate gelatin light-sensitive hydrogel to make a composite scaffold for use in the repair of bone lesions in the jaw and face. It is hoped that the design and construction of bone scaffolds using a 3D bioprinter in the current research will help localize the knowledge and technology of bone tissue repair scaffolds. In this project, the effort will be to design and prepare a suitable biological ink in terms of biological and mechanical properties for 3D bioprinting of bone scaffolds. Preparation of bone scaffolds suitable for each patient's bone defect can bring better restorative results from the point of view of medical aesthetics and ultimately greater satisfaction of the patient.

Moderator: Dr. Nasrin Lotfi Bakshaish

Start year: 2023