Effects of nHA-coated subperiosteal implants on the Expression of ECM-Related Genes in Gingival Fibroblasts
Summary of the necessity of implementation
Titanium and alloys are currently the most widely used materials for making dental implants. However, in partially or completely edentulous patients, various degrees of maxillary bone resorption usually occur, making the use of these appliances difficult or even impossible. In the face of such cases, we generally turn to alternative options to eradicate the toothless treatment process of people, which can include bone grafting surgeries using bone grafts or using other bones in the body, which in their own way have different opinions such as length The treatment process, the treatment success rate, the difficulty of the treatment process and also the final cost have many challenges. Another of these alternative treatments that are applicable in these cases is the use of subperiosteal implants, which are mostly independent of the bone thickness and can provide a good alternative to endosteal implants, even today with the use of fully digital workflows for These types of implants, which allow us to use titanium alloys with different methods such as milling and 3D printing of metals, we are witnessing a revival of interest in these devices in the field of implantology, followed by a wave of new concepts in this field. Due to this increase in demand, it is necessary to combine new science with old knowledge and provide the best solutions to improve and upgrade this type of implants, because one of the common problems in these implants, which we generally see in different cases, is It is the resorption and decay of the gums and bones, which ultimately leads to the exposure of the metal in the mouth and does not leave a pleasant appearance. With a careful review of the research done in this field in recent years and the use of different surface treatments to increase the adhesion of the gum to the surface of these implants, as well as the research done in the past that uses methods such as covering the surface of these implants with hydroxyapatite Along with the new articles in the field of nanomaterials focusing on nano hydroxyapatite, we noticed a gap and convergence between these two fields and we decided to investigate the effect of nano hydroxyapatite coatings on titanium surfaces of subperiosteal implants on the expression of related genes. with ECM in gingival fibroblasts and examine the adhesion of fibroblasts.
Start year: 2024
Project manager: Ali Ranjbar
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