Summary of the need to implement the plan

HNSCC is the sixth most common cancer in the world, and despite the progress made in the field of diagnosis and treatment of this disease, the death rate due to HNSCC is still high. Considering that OLP is considered as a pre-malignant lesion, few genetic studies have been conducted on the nature of the course of genetic changes in the malignant process of these lesions. Recently, the role of epigenetics in the process of cell changes has led to more pronounced malignancy. One of these cases are LncRNAs, which are involved in molecular biology processes including changes in cell transcription, DNA looping, and the formation of nuclear components, and in this way, they can be involved in the processes of proliferation, resistance to apoptosis, induction of angiogenesis, and promotion of metastasis in cancers. have a role.

Start Year: 2019

The project manager: Dr. Narges Gholi Zadeh