Summary of the necessity of project implementation

Alzheimer's is a neurodegenerative disease for which no effective treatment has been reported so far. One of the main ways of causing the disease is the accumulation of beta amyloid plaques outside the cell and neurofibrillary tangles inside the cell, which results in the cessation of cell growth, the loss of nerve cells and the reduction of neurogenesis and synaptic connections between neurons, which is a change in the brain's electrical activity in the EEG. Patients can be seen. Although a lot of research has been done on the ability of mesenchymal stem cells in the compensatory and restorative mechanisms of the brain and the treatment of neurodegenerative diseases such as Alzheimer's, but the accompanying problems such as immune incompatibility, tumorigenicity, the possibility of infections, low number of cells for transplantation or Death of transplanted cells reduces the efficacy of cell-based therapy. As a result, the use of alternative methods such as the use of paracrine substances of mesenchymal stem cells, one of the most important of which are exosomes, has been considered due to their high potential, low cost and less stimulation of the immune response. On the other hand, recent research has shown that the culture of stem cells in hypoxia not only has positive effects on the functional efficiency of the cells themselves, but also improves the potential of exosomes derived from them in many fields, including cell growth and differentiation. Therefore, the aim of this study is to use exosomes derived from stem cells under hypoxia intranasally in improving brain function in Alzheimer's disease.

Start year: 2024

Project manager: Dr. Maryam Farhamand Far