May 10 2025
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Craniomaxillofacial Research Center

  • Release Date : Apr 30 2025 - 11:35
  • number of visits : 9
  • Study time : 1 minute(s)

The Role of Oral Microbiota in the Development of Oral Squamous Cell Carcinoma Using MicroRNA and Apoptosis-Related Gene Expression: An Exploratory Study

The Role of Oral Microbiota in the Development of Oral Squamous Cell Carcinoma Using MicroRNA and Apoptosis-Related Gene Express {faces}

Abstract


Background and Objective: Oral cancer is one of the malignant tumors of the head and neck region, which is associated with high mortality rates and has various negative effects on the aesthetics of patients. Therefore, access to high-quality care for early detection and appropriate surgical and drug treatments is crucial. To this end, researchers are investigating the mechanisms of carcinogenesis in cells and identifying the factors that affect it. The aim of this study was to investigate the mechanisms by which oral microbiota contributes to carcinogenesis. Materials and Methods: Sixty peripheral blood samples were collected from oral squamous cell carcinoma (OSCC) patients with (30 samples) and without (30 samples) of oral infection, referred to the Cancer Institute of Tehran University of Medical Sciences. Real-time PCR was performed to determine the expression levels of miR-92, miR-26, miR-486, Bak, Bax, and Caspase-8 genes. Results: MiR-92 and miR-26 relative expression were higher in the OSCC patients with oral infection compared to OSCC patients without oral infection. However, relative expression of miR-486, Bak, Bax, and Caspase-8 was significantly decreased in patients with oral infection compared to OSCC patients without oral infection. Conclusion: The results showed that oral microbiome prevents apoptosis and promotes the development of cancerous tissue in OSCC patients. The identification of a link between oral infection and microRNA and apoptosis-related gene expression could provide researchers with the opportunity to formulate innovative methods for the prevention or management of OSCC.
  • Article_DOI : https://doi.org/10.31557/APJCP.2025.26.4.1225
  • Author(s) : naghmeh bahrami,abodoreza mohamadnia,mohammad bayat,melika norouzi,zahra gharayagh zandi
  • News Group : مقالات,کارشناس مقالات.
  • News Code : 296326
مدیر سیستم
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مدیر سیستم

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