Proteomic and Metabolomic Analysis of Oral Squamous Cell Carcinoma Cells for the Identification of Oral Cancer Biomarkers

Necessity of Project Implementation

Oral cancer, particularly oral squamous cell carcinoma (OSCC), is among the most common cancers in the head and neck region, characterized by high mortality rates and late-stage diagnosis. Current diagnostic methods mainly rely on clinical examinations and biopsies, emphasizing the need for molecular and biological markers for earlier and more effective detection. In recent years, proteomics and metabolomics have emerged as critical tools for studying biological changes associated with cancers, particularly OSCC. Proteomics focuses on analyzing proteins, while metabolomics examines metabolites, providing valuable insights into the cellular and tissue states at various disease stages. Research has demonstrated that alterations in protein and metabolite profiles can serve as indicators of pathological and cancerous processes. A deeper understanding of these changes could significantly contribute to developing non-invasive methods for early diagnosis and improving targeted therapies for oral cancer. This, in turn, could enhance survival rates and the quality of life for patients.

Principal Investigator: Dr. Ziba Vaisi Malekshahi
Start Year: 2024