According to the Public Relations Office of the Vice-Chancellor for Research and Technology at Tehran University of Medical Sciences, a research project entitled “Enhancing Osteogenic Differentiation of Mesenchymal Stem Cells in a Laboratory Environment through Sustained Release of Dexamethasone in 3D-Printed Hybrid Scaffolds Based on Polycaprolactone–Nano-Hydroxyapatite/Alginate–Gelatin for Bone Regeneration” has been successfully completed in 2025 (1404 SH). The project was conducted by Dr. Naghmeh Bahrami, Associate Professor at Tehran University of Medical Sciences and Head of the Craniofacial Surgery Research Center. This valuable research, focusing on the development of personalized prosthetics and the use of 3D bioprinting technology in regenerative medicine, represents a significant step toward the repair and reconstruction of bone tissues, particularly for patients suffering from facial and jaw bone defects. Dr. Bahrami explained the objectives of her study, stating: “In this research, hybrid bio-scaffolds composed of polycaprolactone and nano-hydroxyapatite were designed and printed, incorporating adipose-derived mesenchymal stem cells and dexamethasone-loaded microspheres. The goal was to reconstruct the orbital floor bone while promoting the differentiation of stem cells into bone-forming osteoblasts.” She emphasized that the integration of bioprinting technology, biocompatible materials, and controlled drug delivery constitutes one of the most innovative aspects of this project. In this approach, living cells, biomaterials, and drugs were simultaneously utilized during the bioprinting process to fabricate scaffolds mimicking the natural structure of bone, capable of growth and regeneration within the human body. Dr. Bahrami further added: “The results showed that the gradual release of dexamethasone within the scaffold structure significantly enhanced osteogenic differentiation of mesenchymal stem cells and improved the quality of bone tissue regeneration. These findings can serve as a foundation for designing intelligent, patient-specific prostheses for craniofacial reconstruction surgeries.” According to the faculty member, the primary beneficiaries of this research include medical doctors, dentists, and patients in need of jaw and facial prosthetics, and its outcomes could soon be applied in clinical and practical settings. She noted: “The ultimate goal of this research is to reduce the need for repeated surgeries and improve the quality of life of patients suffering from bone destruction in the facial and jaw regions due to accidents, tumors, or congenital defects. This project, built upon an interdisciplinary collaboration between engineering, biomaterials, and reconstructive surgery, opens new horizons in the field of regenerative medicine in Iran.” This research, relying on advanced 3D bioprinting technologies and the use of human stem cells, stands out as one of the pioneering examples of technological innovation in medical sciences. It contributes to the commercialization and development of indigenous tissue regeneration technologies. In conclusion, Dr. Bahrami expressed her hope that continuing this line of research will soon make it possible to produce highly biocompatible, patient-specific prosthetics capable of true bone tissue regeneration for patients in Iran. Researchers and interested individuals may contact Dr. Naghmeh Bahrami via email at: naghmehbahrami@gmail.com